Exercise in a pill could offer solutions for at-risk patients ANU researchers

Friday 3 December 2021
“Exercise in a pill” could offer solutions for at-risk patients suffering from neurological diseases such as Alzheimer's and Parkinson's.
Exercise in a pill could offer solutions for at-risk patients ANU researchers

Researchers from The Australian National University (ANU) have identified unique molecular signals in the body that could hold the key to developing a supplement capable of administering the health benefits of exercise to patients incapable of physical activity. 

The molecular messages are sent to our brain and potentially our eyes immediately after we exercise. 

The ANU team is conducting research to better understand what impact these molecular messages have on retinal health, but also the central nervous system and eye diseases such as age-related macular degeneration (AMD). 

Associate Professor Riccardo Natoli, Head of Clear Vision Research at ANU, says the molecules could potentially be hijacked, recoded and "bottled up" in a pill and taken like a vitamin.  

"The beneficial messages being sent to the central nervous system during exercise are packaged up in what are known as lipid particles. We are essentially prescribing the molecular message of exercise to those who physically aren't able to," he said.

"We think that as you age, the ability to communicate between the muscles and the retina starts to be lost. Similar to taking supplements, maybe we can provide genetic or molecular supplementation that enables that natural biological process to continue as we age. 

"Our goal is to figure out what these molecules are communicating to the body and how they're communicating." 

Dr Joshua Chu-Tan, also from the ANU Clear Vision Research Lab, says further research is needed to understand how these molecular signals, which are sent from the rest of the body when we exercise, actually reach our brain and eyes. 

He says the team's preliminary research into the benefits of exercise on the retina has unearthed some "promising" results. 

The futuristic therapy could one day help patients suffering from neurological diseases such as Alzheimer's and Parkinson's.  

"It's been suggested that prescribing exercise to patients suffering from neurodegenerative diseases such as Alzheimer's and Parkinson's can help improve and slow down the disease progression," Dr Chu-Tan said. 

"We know that from looking at diseases like Alzheimer's and Parkinson's if you exercise in a particular fashion you can potentially stimulate neuronal activity.  

The researchers say the supplement would be intended only for patients who have restricted movement that renders them unable to exercise at an intensity needed to reap the rewards. It is not intended for the general public. 

"We can't possibly package all the effects of exercise into a single pill, there are too many benefits that stretch throughout the entire body beyond what we could 'prescribe' and that's not the goal," Dr Chu-Tan said.  

Study a Bachelor of Medical Science at ANU and follow in the footsteps of Nobel Prize winner Howard Florey to kick-start your career in medical research.

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Excerpt from ANU Research News 1 Dec 2021

Image credit: Tracey Nearmy

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